All Abstracts

Mechanically agitated tanks are widely used in the chemical and biochemical industries. The flow developing in mixing tanks is highly complex and three-dimensional. Although few attempts have been made to locally measure the three components of velocity in the three spatial directions, the experimen...

Continuous-flow mixers operating under chaotic advection enable efficient mixing of both highly viscous and low-viscosity liquids, including those containing components sensitive to high shear rates typical of turbulent flow. Chaotic advection ensures rapid development of intermaterial surface area ...

This work introduces an Artificial Intelligence–assisted Radioactive Particle Tracking (RPT-AI) framework for rapid and quantitative characterization of multiphase hydrodynamics in mechanically agitated reactors. The approach combines robotized calibration with deep neural-network reconstruction t...

Rotary disc contactors (RDCs) are widely used for liquid–liquid extraction, but quantifying axial back-mixing in multi-stage units remains difficult. Here, CFD-generated tracer pulse responses are combined with a stage-wise N-CSTRs-in-series model with back-mixing to identify effective mixing para...

Batch rotor-stators are used in several dispersion processes that require the breakup of immiscible droplets, particle clusters or for foam generation on account of the high turbulence energy dissipation rate in the vicinity of the mixer head. The overall process performance also relies on minimal s...

Predicting the performance of high-pressure homogenization (HPH) remains a significant challenge in CFD due to the complex coupling of high-shear turbulence and transient cavitation. While cavitation has an essential impact on droplet breakup and cell lysis in food and biotech applications, its stoc...

The industrial-scale production of adeno-associated virus (AAV) by transient transfection of HEK293 cells remains a key challenge for gene therapy manufacturing. Scaling from shaken culture systems to stirred tank bioreactors introduces changes in hydrodynamic conditions, where biological and engine...

In the cooling crystallization process for potassium chloride production from seawater-derived concentrated brine, small crystal growth rate results in small crystals and poor solid–liquid separation efficiency. To address this issue, a draft tube (DT) is often placed in stirred vessels to control...

Pharmaceutical formulations containing low bulk density components present challenges in powder flow and handling. High-shear wet granulation (HSWG) is widely used to improve powder handling and produce granules with controlled particle size. The scale-up of HSWG remains challenging due to several s...

Despite the fact that computational modelling in multiphase flow mixing has aroused interest over the past 40 years or so, its role and usefulness still remain unclear. This presentation will attempt to bring elements of answer to this question by reviewing some of the most significant techniques an...

Estimation of power number and mixing characteristics lab-scale stirred reactors without wall-mounted baffles remains a major challenge in computational fluid dynamics (CFD) because of the complex intimate interaction between impeller-induced flow structures, free-surface deformation, a more or less...

This work focuses on a novel method that provides a unique solution to the closure problem occurring in reactive turbulent flows. So far, closure models have been developed for both single and competitive reactions, such as competitive–parallel and competitive–consecutive schemes; however, more ...

Gas scrubbing plays a critical role in ensuring clean industrial emissions and meeting increasingly stringent environmental regulations. Maximizing its performance depends strongly on the efficiency of the underlying mass transfer processes. The utilization of static mixers is known to significantly...

Micro-fluidized beds (MFBs) are attractive intensified gas–solid contactors because of their high heat and mass transfer potential. However, strong wall confinement in small-diameter columns often promotes severe slugging, which deteriorates gas–solid mixing and limits stable operation. In this ...

Predicting heterogeneities in bioreactors is crucial for scaling up fermentations, as spatial gradients can strongly influence microorganisms and fermentation performance. Although Computational Fluid Dynamics (CFD) coupled with biokinetic models can capture these effects, such simulations are compu...

In vitro cultivation of human inducible pluripotent stem cells (hiPSCs) for the production of Red Blood cells (RBCs) is a promising therapeutic alternative to donor-based blood cell transfusions. The sensitivity of human stem cell aggregates requires a tight balance between hydrodynamic stresses and...

Cultivation of mammalian cells is typically performed in stirred and aerated bioreactors, where cells are exposed to complex hydrodynamic forces generated by mixing and aeration. While adequate mixing is essential for efficient heat and mass transfer, maximum hydrodynamic stress (τmax) can impact c...

In high-viscosity mixing, deformation accompanied by stretching/compression and repeated reorientation plays an important role; however, quantitative methods for evaluating mixing performance have not yet been fully established. This study proposes a performance-evaluation framework for distributive...

Micromixers are key components of microfluidics and are widely used in research and industry. Micromixers offer many benefits, such as rapid mixing, portability, safety, and low cost. Due to the low Reynolds numbers in microscale flows, the fluid is laminar, making it difficult to mix thoroughly, qu...

Double emulsions (DEs) consist of a simple emulsion dispersed within a continuous phase, forming a two-compartment structure. They are widely used for encapsulation and controlled-release applications, such as in the pharmaceutical industry. Their preparation typically involves two steps, where the ...

Transport of soluble gases between bubbles and surrounding liquid is an important phenomenon in many industrial processes such as bio-reactor aeration, stripping, absorption, and electrolysis. An effective tool to understand such systems is numerical simulation of the relevant conservation equations...

This study investigates the mixing performance of a newly designed impeller developed to improve homogenization efficiency in high-viscosity systems while maintaining the grinding and dispersion performance characteristic of the Cowles-type geometry. Experimental observations indicate that the limit...

Continuous antisolvent precipitation has emerged as a scalable method for producing lipid nanoparticles (LNPs), which is known to be a micro-mixing limited process. Several microfluidic devices and meso-scale devices have been developed for antisolvent precipitation. The device design and operating ...

Drop breakup is a vital process of producing emulsions across industries and flow regimes. The effect of turbulence on drop breakup has been extensively studied, likewise, how emulsifiers lower the interfacial tension between phases, affecting the coalescence and initial breakup in laminar flows. Ho...

The monitoring of suspension, deposition, and re-suspension phenomena of aluminium-based adjuvants in pharmaceutical formulation tanks represents a significant technological and regulatory challenge, particularly when operating at low solid volume fractions. Aluminium phosphate adjuvants are widely ...

Inline rotor–stator mixers are widely used in consumer goods manufacturing to accelerate mixing and control microstructure, both critical for product performance and consumer satisfaction. Power input in these mixers is typically described using a two term correlation that separates tank type and ...

New formulation coatings with antimicrobial additives- dispersions of nanoparticles such as titanium dioxide, silica- can be an effective means to minimise the rapid spread of diseases in areas of dense populations (hospitals, schools, in public transport) and difficult-to-clean surfaces. This study...

Understanding of dry mixing in the manufacturing of lithium-ion battery electrodes has the potential to improve process sustainability by either reduction or elimination of organic solvents and consequent energy costs of slurry drying. The dry mixing dynamics of NMC 622, a cathode electrode material...

The mixing characteristics within a stirred tank are influenced not only by the geometry of the mixing system but also by the impeller Reynolds number (Re). In particular, it is well known that poorly mixed regions can form depending on the value of Re. Mixing time serves as an indicator of the time...

Laminar mixing is critically important in industries dealing with high‑viscosity materials, food, and cosmetics, yet conventional anchor impellers operating at very low Reynolds numbers inevitably generate distinct poorly mixed regions between the blades and the central shaft. To address this long...